On 26 May 2026, the European Food Safety Authority (EFSA) published a scientific opinion on the safety and efficacy of a feed additive consisting of riboflavin 80% (vitamin B2) produced with Saccharomyces cerevisiae ATCC SD-8628 for all animal species. The opinion concludes that the additive is safe for target animals, consumers, and the environment under the proposed conditions of use, and that it is an effective source of vitamin B2.
The document, prepared by EFSA's Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), assesses the additive submitted by Amyris Inc. Riboflavin 80% is intended to be used as a nutritional additive (vitamin, pro-vitamin and chemically well-defined substances having similar effect) in feed for all animal species. The FEEDAP panel evaluated data on the production strain, manufacturing process, stability, toxicology, and efficacy.
The opinion confirms that the production strain Saccharomyces cerevisiae ATCC SD-8628 is genetically modified but does not raise safety concerns for target animals, consumers, or the environment. No risks for users handling the additive were identified provided appropriate protective measures are taken. The additive is considered efficacious in meeting the animals' requirements for vitamin B2.
This scientific opinion is a mandatory step in the EU authorisation process for feed additives. The European Commission and Member States will now consider the opinion in the context of a possible update to the EU Register of Feed Additives. The opinion is available on EFSA's website and is open for public consultation for 30 days.
Feed manufacturers and livestock producers will benefit from a new authorised source of riboflavin, potentially increasing supply chain flexibility. Consumers can be reassured about the safety of animal products from treated animals. The additive's producer, Amyris Inc., gains a positive safety assessment supporting market access. No significant negative impacts on competitors or the environment were identified in the opinion.