Healthcare stakeholders issued a joint statement on FP10 and EU collaborative health research frameworks, calling them an opportunity to strengthen Europe’s research ecosystem, boost health innovation, and reinforce global leadership. They stress that tackling tomorrow’s health challenges requires innovative solutions, better-funded programs, and multi-stakeholder collaboration among patient organizations, healthcare professionals, governments, academia, industry, and civil society. With the geopolitical landscape evolving and some governments shifting away from public health, Europe must ensure health remains central to crisis planning and public health preparedness. The authors emphasize maintaining world-class, patient-centered health research and innovation, supported by the EU Charter of Fundamental Rights, and urge ring-fencing funds, more efficient funding rules, and greater collaboration through public-private partnerships (e.g., IHI, IMI, GH EDCTP3, THCS). They present six recommendations to strengthen FP10: preserve stand-alone funding for health, reduce administrative burdens, balance basic and applied research, sustain in-kind private sector contributions, improve exchanges with civil society, and attract and retain talent. The statement argues FP10 can enhance Europe’s resilience, competitiveness, and global health leadership by keeping health as a priority and leveraging civil society and public-private partnerships.